Pharmacological effects
The small amount of Isosorbin has an excitatory effect on the central nervous system of frogs, mice, and rabbits, and a large number of them are transferred from excitement to paralysis; the smallest lethal dose is 0.5 mg/g for frogs and 0.1 mg/g for mice. 10mg/kg. The rabbit's breathing and blood pressure were slightly suppressed. The decompression is due to peripheral vasodilation and direct inhibition of the heart and has nothing to do with the vagus nerve. There is a direct paralysis effect on the isolated frog heart, and the heartbeat stops at the expansion phase. A small amount of excitement on the isolated small intestine and uterus, the first amount of excitatory numbness after the first, a lot of it was paralyzed at the beginning; pregnant uterus is particularly sensitive to the excitatory effect of the concentration of 0.000001% rabbit uterine, and 0.00001% concentration It is inhibited; the appropriate dose of intraperitoneal injection to pregnant rats can cause fetal death and subsequent ovarian dysfunction. It has an unpleasant, corrosive, bitter taste that can be used to foam or treat certain skin parasites. In addition, there are some antibacterial effects. Chloroform extracts from roots have a significant antibacterial effect against Staphylococcus aureus (Oxford Small Cup method). It also has a certain inhibitory effect on Salmonella typhimurium and Shigella flexneri, followed by petroleum ether extracts and ethanol extracts more often. The water extract has no anti-bacterial effect. The root contained 1 :100000 of plumbagin has inhibitory effects on some pathogenic molds.
Adverse reactions
Plumbago is toxic and can cause respiratory depression, blood pressure drop, and cardiac arrest. The skin contacted with the leaves and root fluids of Plumbago caused swelling and peeling. Paralysis occurs after ingestion, and miscarriage is caused by misuse of food by pregnant women; Rescue method: skin poisoning can be washed with water or boric acid water; such as erosion with boric acid ointment dressing the affected area. Human poisoning served egg white, sugar water and activated carbon. If numbness occurs, brain stimulants such as camphor can be given symptomatic treatment such as intravenous saline infusion. If pregnant women have miscarriage, they can be sedated and injected with progesterone and vitamin E.
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