Release date: 2015-07-20
American scientists have genetically recombined pluripotent stem cells extracted from human skin to create a micro-ventricle with human heart cells. This "small heart" can behave like a full-sized heart. Researchers say the "mini" organ can replace animal experiments, screen new drugs or test drugs for infants, and will help scientists reveal more of the secrets of human heart formation and development.
Kevin Healy, a collaborator of the study and a professor of bioengineering at the University of California at Berkeley, said in an interview with the British Daily Mail on July 15th: "We believe this is the first human micro-ventricle that has been cultivated in test tubes. This technology may help us quickly screen for drugs that may cause fetal heart disease."
He and Bruce Conklin, a researcher at the University of California, San Francisco, Gladstone Cardiovascular Institute, used biochemistry and biophysics to promote stem cell differentiation and self-organization into this tiny heart tissue, including the micro-ventricle. Related research is published in the latest issue of Nature Newsletter.
To test the potential of the system as a drug screening tool, the researchers exposed the differentiated cells to the drug thalidomide, which could cause severe birth defects. They found that at normal therapeutic doses, the drug caused abnormalities in the development of the microventricular, including shrinking size, muscle contraction, and decreased heart rate.
Conklin said: "Each year, about 280,000 pregnant women are exposed to drugs that pose a potential risk to the fetus. The most common birth defects include heart disease. The latest system may significantly reduce the chances of pregnant women coming into contact with toxic drugs. And, despite the latest research The main emphasis is on heart tissue, but new technologies have the potential to produce other body organs."
Previously, scientists used cardiomyocytes from experimental mice to study cardiac micro-tissues, but this is not an ideal model for human disease research. The "mini" heart, developed from human stem cells, has revolutionized this practice and will replace animal experiments in the future.
Source: Technology Daily
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