Vacuum Freeze Dryer Selection Guide

For each lyophilized application area, Bo Pharmacon proposes different solutions.

For research institutes and universities, Bo Medical has introduced FD and Lab series vacuum freeze dryers. The FD series vacuum freeze dryer is suitable for experimental freeze-drying applications where the sample volume is small and the freeze-drying process is relatively simple. In addition to direct FD series directly in the cold trap was dried, the drying process is generally the maximum allowable temperature from room temperature to the product, whether FD series to meet the needs determined from the following:

1. The product eutectic point and the eutectic temperature are not lower than -20 °C.

2. In the case where the amount of single-loading is less than 5 ul , surface dissolution does not occur during the vacuum establishment from the end of pre-freezing.

3. The ultimate vacuum required for the freeze-drying process is not less than 8Pa .

4. The freeze-drying process is relatively simple, and the process does not require pre-freezing temperature and vacuum.

FD series vacuum freeze dryer difference introduction:

1.FD3/4/5/8 is suitable for small and pilot production with relatively low process requirements.

2. The FD-2 series is suitable for lyophilization of products containing small amounts of organic solvents and for low temperature pre-freezing (within a cold trap) for small samples ( <1.5L ). The main aspect of the FD-2 series over the FD-1 series is the configuration of the diaphragm temperature control system and the PLC+ touch screen control system. The main difference between the FD-2 series and the Lab-1 series is the FD-2 series as the basic model. It is not possible to configure all the advanced functions of the Lab (vacuum control system, pulse backfilling system, defrost system, automatic drainage system and APS). Fully automatic control system).

3. The FD-1 series is suitable for freeze-drying applications where process requirements are relatively low. This series offers the basic functions of lyophilization: pre-freezing, vacuuming and cold trap trapping in the trap. For the more advanced application functions, you can choose the Lab-1 series.

Lab-1 Series Applications:

1. The degree of vacuum needs to be adjusted during lyophilization.

2. Sublimation and analytical drying processes require temperature control.

3. A higher ultimate vacuum is required during the lyophilization process.

4. Automatic defrost and automatic drainage function.

5. Freeze dry data and curve search function.

6. Pulsation backfill function after lyophilization.

7. The product eutectic point and eutectic temperature are not lower than -20 °C.

8. The micro-samples show deliquescence during the vacuum build-up process.

9. Lab-1 series process optimization rate can reach 30% .

The Pilot1-2LD/Pilot1-2MD/Pilot2-4LD/Pilot2-4MD models are suitable for laboratory pilot experiments. This series proposes solutions to the following problems.

1. After the product is pre-frozen, deliquescence occurs during the transfer process.

2. The micro-samples show deliquescence during the vacuum build-up process.

3. Pre-freezing temperature needs to be adjusted during sample pre-freezing.

4. Sample Analysis A lower vacuum is required during the drying process.

5. Meet the requirements of the laboratory, the function of the pilot vacuum freeze dryer with complete functions and small footprint.

6. Process optimization rate is 40-70%.

The economical version of the Pilot series is suitable for small and pilot production and is suitable for use in industrial materials, food and health products production processes and optimization (process optimization rate of up to 65% ).

The Pilot series of standard models are suitable for small-scale and pilot-scale research and development in the pharmaceutical and biological preparation fields. Users can choose to wall isolation and non-through wall isolation according to the cleaning requirements. The process optimization rate of this series of models can reach more than 90% , fully meeting the requirements of GMP and FDA .

The LYO series is mainly used in freeze-drying production, and basic type, CIP type and SIP type can be selected according to user requirements . Applications include lyophilization of chemicals, biopharmaceuticals, biological agents, Chinese medicines, health products, high-grade foods, condiments, feed additives, and industrial special application materials.

Domestic and foreign vacuum freeze dryer selection guide

There are many brands in the vacuum freeze dryer market, and many customers have no discriminating ability to choose a brand. From the perspective of market supply, it is mainly divided into: imported brands and domestic brands. The relative price of imported brands is relatively high, and the performance is higher than that of domestic brands. Domestic brands are relatively low in price relative to imported brands, and their functions are relatively simple. The main basis for choosing an imported brand or a domestic brand is:

1. The process requirements of the freeze-drying process are relatively high, and the domestic vacuum freeze dryer cannot meet the process requirements.

2. There is a high requirement for the repeatability and consistency of the vacuum freeze dryer.

3. The upstream separation and purification or downstream packaging inspection equipment is provided by the importer, and the domestic freeze-drying equipment cannot be matched with it.

Note: Choose several traps for imported brand vacuum freeze dryers:

1. As long as it is imported, the quality will be good. Many foreign second- and third-line brand vacuum freeze dryers are far less quality and workmanship than domestic first-line brands.

2. Imported brands are better than domestic brands. In addition to a handful of foreign brands with 2-3 national service capabilities, other manufacturers basically have no service capabilities.

3. The price of imported brands must be higher than the price of domestic brands. The price of foreign first-line brands is higher than that of domestic first-line brands, which is generally 30-40% higher . The domestic first-line brand and the foreign second-line brand prices are basically the same and higher than the foreign third-line brand prices. The reason for this pattern is that in the past five years, some domestic manufacturers have greatly improved their performance and workmanship. The quality and performance of their products have reached the international level, while the products of foreign second- and third-line brands have basically no essential changes.

Mistakes in the selection of domestic brand vacuum freeze dryer:

1. In the selection process, the lower the price, the better. Low prices mean that the functional configuration is very low and may not meet the usage requirements.

2. Select the brand to use price as the first criterion. Manufacturers of the same type of products are relatively low in price, because the scale of production is large and costs can be controlled. If the product offered by a small-scale manufacturer is found to be lower than the price of a large-scale manufacturer, it should be noted that some accessories that the customer cannot pay attention to have been replaced with inferior parts that are relatively inexpensive.

3. Do not pay attention to factory services. Small-scale manufacturers do not have the ability to service. Once a device fails, the customer cannot use the device normally.

4. Try to save money during the selection process, only choose the basic type, and do not consider the higher demand that may exist in the future.

Vacuum freeze dryer non-standard customized service

Experimental vacuum freeze dryer

According to customer needs, the whole machine provides the following non-standard customized services:

1. Cold trap can be customized temperature range: -100 to - 165 °C.

2. Non-standard freeze dry warehouse production, including: freeze dry warehouse size, material, structure type, tray material and size.

3. The size of the whole machine can be customized according to the actual site requirements of the customer.

4. The equipment to be connected by the user and the vacuum freeze dryer match the customized service.

5. The whole machine personalized customization service, including: personalized design of the whole machine shape and personalized design of the display interface.

6. The vacuum unit non-standard custom service can customize the pumping speed and appearance of the vacuum pump according to customer requirements.

7. Customized vacuum freeze dryer for organic solvents can be customized according to customer requirements.

8. High reliability vacuum freeze dryer can be customized according to customer needs. The refrigeration unit, the vacuum unit and the electrical system are both standby machines. One group fails and automatically switches to the second group to ensure long-term stability and reliability.

Pilot type vacuum freeze dryer

According to customer needs, the whole machine provides the following non-standard customized services:

1. Cold trap can be customized temperature range: -100 to - 130 °C.

2. The partition can be customized to a temperature range of -60 to - 100 °C.

3. 0.1 m2 silicone oil type vacuum freeze dryer can be customized according to customer requirements .

4. CIP+SIP ( 0.1 to 1 m2 silicone oil type vacuum freeze dryer) minicomputer can be customized according to customer requirements .

3. The size of the whole machine can be customized according to the actual site requirements of the customer.

4. The equipment to be connected by the user and the vacuum freeze dryer match the customized service.

5. The whole machine personalized customization service, including: personalized design of the whole machine shape and personalized design of the display interface.

6. Nitrogen vacuum freeze dryer can be customized according to customer requirements.

7. Customized vacuum freeze dryer for organic solvents can be customized according to customer requirements.

8. High reliability vacuum freeze dryer can be customized according to customer needs. The refrigeration unit, vacuum unit, circulation unit and electrical system are both standby machines, and one group has a fault. Automatically switch to the second group to ensure long-term stability and reliability.

Production vacuum freeze dryer

According to customer needs, the machine provides the following non-standard services:

1. Design a vacuum freeze dryer according to the customer's site.

2. Design a vacuum freeze dryer according to the customer's freeze-drying process and docking equipment.

3. Customizable tunnel type food vacuum freeze dryer.

Non-standard customized service process:

1. Communication between the supplier and the buyer to confirm the demand information.

2. Provide development cycle and quotation based on demand information.

3. Both parties confirm the detailed requirements information generated and sign the contract.

4. After the completion of the development, the customer enters the factory for inspection.

5. Equipment transportation and installation to the factory.

6. On-site commissioning and training.

7. Service tracking during device operation.

Freeze-drying process optimization service

The lyophilization process can be optimized for different formulation materials, including:

1. Determination of eutectic point temperature.

2. Determination of the melting point temperature.

3. Pre-freezing temperature and pre-freezing time optimization.

4. Optimization of heating rate, vacuum value and heating time in the drying stage.

The purpose of lyophilization optimization is to ensure good appearance, increased activity, reduced nutrient loss and control of product moisture content after lyophilization, and on this basis to improve production efficiency or provide a basis for scale-up production.