Articular cartilage has almost no regenerative ability to self-healing. It is a huge challenge in clinical treatment. Stem-derived exosomes (SC-Exos) are an important type of extracellular nanobubbles for cartilage instead of stem cell-based treatment. Regeneration has shown great potential, but there is currently no effective method of administration that can permanently retain exosomes at the site of cartilage defects and allow them to effectively repair. However, the photo-induced imine cross-linked hydrogel adhesive developed by Wang Wei, a researcher at the Sixth People's Hospital affiliated to Shanghai Jiaotong University and a researcher at East China University of Science and Technology, will change this situation.
It is reported that light-induced imine cross-linked hydrogel adhesive exhibits excellent handling ability, biocompatibility and most important cartilage integration ability, and can be used as an exosomal scaffold for cell-free tissue patch (EHG) for cartilage regeneration. Studies have found that EHG can retain exosomes internally and regulate chondrocytes and hBMSCs in vitro. In addition, EHG can also integrate with its own cartilage matrix, promote cell deposition in the cartilage defect, and ultimately promote the repair of cartilage defects, the researchers said, hope that EHG tissue patch can provide a new cell-free scaffold material to help wound repair.
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