[China Pharmaceutical Network Technology News] When new drugs are tested in humans, sometimes they have little effect and sometimes endanger the lives of patients. Drug testing in an organization does not involve the entire body, saving money, time and life. A very small blood vessel made by a new system can change the way drugs are tested. Perhaps one day in the future, this technology can be used to quickly build human organs. 
Scientists at Duke University's Pratt School of Engineering have published a new method for making blood vessels in Scientific Reports. In fact, it is much more complicated than it sounds. Blood vessels are not such simple things as "some pipes". Each blood vessel contains a layered structure with interaction between the layers. It takes weeks to make all the layers, and the new technology allows them to complete in a matter of hours.
The innermost layer is called the endothelium, and the endothelial cells are rearranged as the blood vessels are positioned. Endothelial cells are surrounded by a layer of smooth muscle cells that compress blood vessels to restrict blood flow or enlarge blood vessels to allow more blood to flow through. The new technology includes two situations.
The first step is to suspend the cells in a collagen gel. The image above shows the cells suspended in collagen and shows the next step – removing the large amount of water from the collagen. Let the artificial blood vessels be smaller than the blood vessels in the human body, allowing scientists to make artificial blood vessels for testing within a few hours.
To ensure that artificial blood vessels can function like blood vessels in the human body, researchers use known drugs to test artificial blood vessels. They exposed artificial blood vessels to acetylcholine, a drug that dilates blood vessels. When the blood vessels dilate, they let the blood vessels contact phenylephrine, which causes the blood vessels to contract. After vasoconstriction, the inflammatory response is still reduced as designed. Now, researchers want to know if cells with specific genetic diseases react with drugs in the same way as they do in humans. If successful, new drugs can be tested with these artificial blood vessels before being tested in humans.
The innermost layer is called the endothelium, and the endothelial cells are rearranged as the blood vessels are positioned. Endothelial cells are surrounded by a layer of smooth muscle cells that compress blood vessels to restrict blood flow or enlarge blood vessels to allow more blood to flow through. The new technology includes two situations.
The first step is to suspend the cells in a collagen gel. The image above shows the cells suspended in collagen and shows the next step – removing the large amount of water from the collagen. Let the artificial blood vessels be smaller than the blood vessels in the human body, allowing scientists to make artificial blood vessels for testing within a few hours.
To ensure that artificial blood vessels can function like blood vessels in the human body, researchers use known drugs to test artificial blood vessels. They exposed artificial blood vessels to acetylcholine, a drug that dilates blood vessels. When the blood vessels dilate, they let the blood vessels contact phenylephrine, which causes the blood vessels to contract. After vasoconstriction, the inflammatory response is still reduced as designed. Now, researchers want to know if cells with specific genetic diseases react with drugs in the same way as they do in humans. If successful, new drugs can be tested with these artificial blood vessels before being tested in humans.
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