Can "healthy bacteria" transplants resist aging?
June 26, 2017 Source: Guangzhou Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Medical Guidance/Deputy Dean of the First Affiliated Hospital of Guangdong Pharmaceutical University, Chief Expert of Gastroenterology, Professor He Xingxiang, Micro-Ecological Treatment Team
Life, old age, illness, and death are the laws of nature. Even so, human beings have always been obsessed with the desire and pursuit of immortality and longevity. Since the development of modern medicine, anti-aging research and exploration have become more and more, and every new discovery has attracted much attention.
Not long ago, a study published in Nature published that the lifespan of the "young" African green carp was colonized in the "middle-aged" African squid. Popularly speaking, it is the transplanting of the squid of young squid to make the old carp live longer. This application of bacterial colonization to anti-aging animal research has attracted widespread attention in the medical and scientific community: is the same practice applied to the human body?
Case
Old people transplant "healthy bacteria"
The 89-year-old Li Laobo was diagnosed with a differentiated adenocarcinoma of the sigmoid colon four years ago. After surgical treatment of resected lesions, he repeatedly developed symptoms such as abdominal distension, poor appetite, and fatigue. His mental state was not so good, and he even suffered from depression.
In the past four years, his family took him to several hospitals for treatment, but the symptoms were still repeated. Some time ago, he bloated again, and at the same time he had a change in stool characteristics. He was sent to the First Affiliated Hospital of Guangdong Pharmaceutical University. After fully evaluating his condition, the Department of Gastroenterology Micro-Ecological Treatment of the Department of Gastroenterology recommended that he accept the “reconstruction of intestinal micro-ecology†treatment. After obtaining the consent of him and his family, the treatment team extracted the intestinal “healthy bacteria†from the recruited healthy volunteers and transplanted him. After one week of treatment, Li Laobo's symptoms of bloating and poor appetite were significantly improved and he was discharged smoothly.
Two weeks after leaving the hospital, the family was delighted to find that the mental condition of the elderly was obviously improved. We sent a WeChat to the doctor, saying that the old man was "more gratifying, his face was obviously younger, white and clean (not pale), and the spots were gone. It seems to have done beauty."
Frontier Research
Flora transplantation anti-aging attention is currently only reported in animal experiments
“Although there have been no reports of the use of bacterial flora for human anti-aging treatment, relevant animal experiments have been reported.†Professor He Xingxiang, chief expert of the Department of Gastroenterology, the First Affiliated Hospital of Guangdong Pharmaceutical University, told Reporter, not long ago, a study published in the world famous "Nature" magazine found that the intestinal flora can prolong the life span of African green carp. African green mullet is a short-lived vertebrate that usually lasts only a few months.
In this study, the researchers extended their lifespan and delayed their ability to exercise by allowing the intestinal bacteria of the “young†African green carp to colonize the “middle-aged†African squid. Recession; further research has also found that "young" flora characterized by an increase in key bacterial genera such as Microbacterium can inhibit the decline in intestinal flora associated with host aging and help maintain "young body" in the host "The composition of the intestinal flora." The application of this applied flora to anti-aging animal research has aroused heated discussion and extensive attention in the medical and scientific community.
“More and more research is focusing on the relationship between gut microbiota and aging.†He Xingxiang said that studies have found that the immune system is degraded and low-grade chronic inflammation leads to changes in the intestinal flora, accompanied by aging. Disease. The diet and probiotic interventions targeting the flora are thought to be beneficial to host health and anti-aging through antioxidant activity, improving immune balance, inhibiting chronic inflammation, regulating fat deposition and metabolism, and inhibiting insulin resistance. influences.
The internationally renowned medical journal Cell has recently issued a report that the development of chronic inflammation has a lot to do with the high morbidity and mortality of the elderly. With the aging of the body, the intestinal barrier function will be weakened, and the bacteria in the intestine can reach other parts of the body through the barrier, causing the body's immune response and promoting the development of inflammation. Experiments in sterile mice have confirmed that the gut flora in the elderly can increase the permeability of the intestine and promote the inflammatory response of the body. In this sense, improving intestinal micro-ecology will have a positive effect.
expert's point
Prospects for anti-aging therapy
"From the perspective of existing animal studies, the regulation of the intestinal flora has indeed added a glimmer of light to the treatment of human anti-aging to some extent." He Xingxiang said that many studies have reported that during the aging process of the body, The number and types of probiotics in the intestines have decreased. Some scholars believe that by increasing the supply of human probiotics, anti-aging effects may be achieved. He believes that these views fully affirm the important relationship between intestinal probiotics and aging.
“However, as a super micro-ecological system, the intestinal flora is a large number and variety, and it is necessary to consider more the interaction between microorganisms and the effects of their metabolites on the body.†Therefore, he believes that through overall comprehensive health Bacterial transplantation, rebuilding the body's healthy and energetic intestinal micro-ecology may become one of the promising anti-aging treatments.
“The whole, comprehensive 'healthy bacteria' transplant will play a more important role like 'organ transplantation'.†He further explained that the intestinal flora is a huge micro-ecological system, the number of up to 10 14th, is the human body. More than 10 times the total number of cells, from this definition, a person can be defined as a complex of the human body and the microbial community or a super ecosystem. Through the transplantation of a whole and comprehensive "healthy bacteria", it helps to reconstruct the intestinal micro-ecological balance, enhance the body's antioxidant activity, improve immune function, inhibit chronic inflammation, regulate fat deposition and metabolism, inhibit insulin resistance, and thus the health of the body. And delaying aging has a positive effect. This is why Li Laobo accepted the "fertilization transplant" half a month after the "mental condition improved significantly, his face became significantly younger." However, he admits that the "younger" effect similar to that obtained by Li Laobo is only "unexpected discovery" and needs further clinical research.
Clinical application
Flora transplantation has a good effect on various diseases
He Xingxiang told reporters that although there has been no report on the use of bacterial flora for human anti-aging treatment, the transplantation of microflora has been applied in some diseases with poor efficacy of traditional treatment methods, such as intestinal diseases such as inflammatory bowel disease. Diseases, chronic liver diseases such as hepatitis B and cirrhosis, metabolic diseases such as metabolic syndrome and diabetes, and neurological diseases such as autism, depression and other mental diseases such as epilepsy.
According to him, the First Affiliated Hospital of Guangdong Pharmaceutical University has been carrying out “healthy bacteria†transplantation therapy since December 2016, and extracted it from the feces of recruited healthy donors with the “Seco Separation Systemâ€. Intestinal "healthy bacteria" was transplanted for nearly 100 patients with good results. He explained that the so-called "healthy bacteria" transplant is to transplant the functional flora in the human feces into the patient's intestines, rebuild the new intestinal flora, and balance the intestinal flora to achieve the purpose of treating diseases. This therapy has been included in the United States as a treatment guide for Clostridium difficile infection. (Text / All-Media Reporter Weng Shuxian Correspondent Pan Yingyuan)
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