A paper published in the United States on the 18th in the journal Science Translational Medicine revealed a pathogenesis of non-alcoholic fatty liver-induced liver cancer. The article said that an anti-fungal drug that has been approved by the US Food and Drug Administration has the efficacy of preventing and treating such liver cancer.
Department of Internal Medicine and Therapeutics, Faculty of Medicine and Therapeutics, Chinese University of Hong Kong, China, together with researchers from Professor Yu Jun and Liu Dabin, analyzed the genome expression of hepatocellular carcinoma tumor tissues and adjacent liver tissues induced by non-alcoholic fatty liver, and found that hepatocytes during liver cancer The expression level of squalene cyclooxygenase was significantly increased.
Yu Jun told Xinhua News Agency reporters that "squalene cyclooxygenase" is a key enzyme in cholesterol synthesis in the human body. Overexpression of it promotes the accumulation of cholesteryl esters in liver cells and increases the level of oxidative stress. The latter changes intracellularity. Methylation levels, thus promoting the occurrence and development of liver cancer.
The researchers constructed a transgenic mouse model with high expression of squalene epoxidase in hepatocytes and fed high cholesterol and high fat foods. The results showed that compared with wild mice, the incidence of hepatocellular carcinoma in experimental mice was significantly increased, suggesting that "squalene cyclooxygenase" may be a potential therapeutic target for non-alcoholic fatty liver-induced liver cancer.
The experiment also found that a commonly used antifungal agent “terbinafine†can effectively inhibit the expression of “squalene cyclooxygenase†and significantly inhibit the growth of tumor cells and the occurrence of liver cancer mediated by this enzyme. Prolong the survival period of liver cancer mice. The researchers believe that the mechanism of action of this drug is to reduce hepatic cholesterol accumulation and oxidative stress levels.
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