With the development of medical science and technology, the diagnosis and treatment of early cancer has become the top priority of preventive medicine in China, and it is also an important goal of precision medicine. On May 25th, Sun Xiaorong, Chairman of Shenzhen Landing Medical Laboratory Co., Ltd., shared the company's innovation in the field of precision diagnosis at the "Big Data and Precision Medical Frontier Technology Application Innovation" forum of the 2nd Guangdong Academician Summit. . According to reports, after 15 years of research and development, the company has developed a cell DNA automatic detection analyzer. It is expected that cell samples will be scanned and analyzed one by one in the asymptomatic phase of the human body to determine whether there are cancerous cells.
Status: There is a large human error in cytological diagnosis
According to reports, in China, more than 80% of cancer patients have been diagnosed in the middle and late stages. "Why can't the advanced stage of the tumor be cured, because the cancer cells break through the body membrane, and the surgical treatment and radiotherapy will completely eliminate the cancer cells, and it will recur." Sun Xiaorong said, but when people have no symptoms and have not formed a mass, Tumors are hard to find. The diagnosis of advanced tumors is mainly based on X-ray, CT, nuclear magnetic resonance, B-ultrasound and other imaging diagnosis. The imaging findings are all tumor masses, and the tumor mass is composed of thousands of cancer cells.
Therefore, many researchers hope that through the method of cytological diagnosis, early diagnosis and treatment of diseased cells in the precancerous stage or early stage of the tumor, killing the tumor in the bud state, reducing the incidence of tumor. Cytological diagnosis is the preferred method for cervical cancer screening at home and abroad. In developed countries, cytology has received much attention. There are cell schools that train cell technicians, and their pathologists must also look at cells. "But, in China, there is no cell professional, there is no cell technician training school. Our histopathologists found that the mass was cut off and then looked at the cells under the microscope to see if the lesions occurred. This is our gap." Sun Xiaorong said And there are also large human errors in cytological diagnosis using microscopy.
After 15 years of repeated research and development, Sun Xiaorong team established a cytological morphological analysis model and cell algorithm, and used computer image processing technology to analyze the DNA content and cytoplasm morphology of the specially stained nuclei, thereby obtaining the diagnosis of DNA content and cell morphology. Information that assists the clinician in determining whether the cell has cancer and cancer.
Breakthrough: Machine scans the nucleus to determine the extent of the lesion
Sun Xiaorong introduced that the DNA cell automatic detection analyzer is a fully automated process that uses the optical, mechanical, electrical, mirror plus computer technology to extend the field of view of the microscope into the nucleus, determine the DNA content in the nucleus, and realize scanning, diagnosis, and reporting. The history of reading under the microscope has solved the cell diagnosis error caused by human factors, and the sensitivity is over 90%.
“Put the film to be tested on the device, the device will automatically scan every cell on the slide. In just two or three minutes, a color cell image report will be generated, and the problematic cells will be red. Boxing out." Sun Xiaorong said that this report is quantitative, it will count how many cells have been swept, and how many cancerous cells and normal cells will be shown in the report.
It is worth mentioning that the innovation of this system is to combine the intelligent digital diagnosis of cells with the artificial experience diagnosis to achieve accurate diagnosis of cells.
Sun Xiaorong said that after the report has been produced, it will be reviewed. After all, the report is done by the robot [-1.01% fund research report], and the review work is undertaken by the doctor. "When the doctor goes to do the review, there is no need to go down the microscope. To find cancerous cells, you only need to find the cells out of the box, and then put these diseased cells together. With a mouse, these diseased cells can be seen immediately under the microscope."
Due to the innovation of robotics, the simple and repeated cell detection work was given to the machine, and the cytopathologist's duties changed. From then on, he only had to make an accusation and review.
"This device can reduce the workload of cytopathologists by 85% and the accuracy is higher." Sun Xiaorong said. According to reports, Landing has completed more than 1 million cervical cancer screening before screening. A large amount of data proves that automated cellular DNA diagnosis exceeds the existing artificial microscope diagnostic cell technology.
Sun Xiaorong revealed that with the Internet of Things, Landing is building a cell diagnostic cloud platform, which is an automated cell diagnostic on the cloud platform. “After the cell is scanned, it is transmitted to the cloud platform through the Internet for diagnosis. After the diagnosis, the pathologist can only generate a report of automation, intelligence and standardization.†Sun Xiaorong said that there are 300 million women in China who want to have a cervix. Cancer screening, if diagnosed through this cloud platform, only a small number of doctors review, can allow grassroots women to directly enjoy higher-end cervical cancer screening services, while reducing the workload of outpatient doctors.
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