The British journal Nature recently published a biological study: a team of American scientists reported the causal relationship between aging cells and neurodegeneration through transgenic mouse experiments, and the latest findings will open a way to treat neurodegenerative diseases. Potential new treatment pathways.
Over time, cell proliferation and differentiation and physiological functions will gradually decline. It is the dynamic balance between cell aging death and neonatal cell growth, maintaining the normal life activities of the body. However, past studies have shown that with age, aging cells (dysfunctional cells that lose their ability to divide) accumulate in the body and actively promote tissue degeneration. Removing these cells can counter many of the effects of aging. Senescent cells have also been detected in the context of brain aging and neurodegenerative diseases, but their role in this is unclear.
This time, the American Mayo Clinic scientist Darren Beck and colleagues used transgenic mice to simulate neurodegenerative diseases and reported the accumulation of aging cells in the hippocampus and other brain regions. Removal of these cells by genetic modification throughout the life of the mouse reduces neuronal tau phosphorylation (and subsequent accumulation of neurofibrillary tangles) and prevents neuronal degeneration in the cortex and hippocampus (both Brain regions participate in cognitive processes). Modified mice exhibited reduced memory loss compared to unmodified mice, which means that senescent cells promote neurodegeneration and loss of cognitive function.
In the accompanying news and opinion articles, scientists at the Massachusetts Institute of Technology believe that the above findings suggest that continuous removal of senescent cells may have a major impact on disease progression before the onset of neurodegenerative disease in model mice. Further research is needed at this stage to determine whether these findings are applicable to humans and whether clinical transformation can be achieved.
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Aging is a slow, irreversible process. After all, once it was a storm, it can only be played next to the fire. It is always difficult to level. This study found through animal experiments that the accumulation of aging cells is associated with a decline in cognitive function, and that the elimination of senescent cells can reduce the memory loss of mice. This means that, at least for mice, people have found a way to get their brain back to normal orbit. The next step is to see if this discovery works in people. If the removal of aging cells can delay the onset of neurodegenerative diseases in the brain, I believe that many people who refuse to accept the old, are willing to join this "anti-aging maintenance luxury package", regularly remove aging cells, give the brain "beauty beauty."
The characteristics of POCT devices determine that they can play an important role in primary medical institutions. In order to standardize and strengthen the application of on-site rapid testing in primary medical and health institutions, promote the rational allocation, safe and effective use of POCT in primary medical and health institutions, give full play to its use value, and ensure the healthy development of medical and health services, "On-site Point-of-care Testing (POCT) Primary The Expert Consensus on the Application of Medical and Health Institutions (hereinafter referred to as the "Consensus") came into being. The consensus was published in the 2019 "China Medical Equipment" magazine after first draft writing, 2 expert on-site discussions, 2 expert online review meetings, and 3 submission revisions. The formulation of the consensus will greatly promote the management standards of the POCT industry, continuously increase the training of grass-roots personnel, deeply understand the application requirements of POCT at the grass-roots level, and promote the rapid development of the POCT industry.
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