For the first time, scientists have identified key proteins that make Zika virus so deadly.
January 05, 2017 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Scientists have little knowledge of Zika virus when it was born. In the past year, researchers have conducted in-depth research to clarify why Zika virus causes a series of dangerous health problems, including neonatal defects, such as small Head deformities and neurological problems (G-Barthew's syndrome, etc.), but the researchers do not know which proteins of Zika virus will make them become lethal, of course, they do not know the mechanism of action of these proteins is what.
Recently, a research report published in the international magazine PNAS , researchers from the University of Maryland Medical School identified the first key protein in the Zika virus to make the virus become killing. The researchers also For the first time, the genome of Zika virus was analyzed in depth. Researcher Professor Richard Zhao said that the mechanism of action of this virus has always been a mystery. This study provides new clues for us to clarify the molecular mechanism of Zika virus affecting cells, and of course it is crucial for the development of new therapies in the later stages.
Globally, Zika virus has infected tens of thousands of people, many of whom are Americans. In the United States and its territories, there are more than 38,000 Zika virus-infected patients, most of them in Puerto Rico; And there are currently no vaccines or preventive measures against Zika virus. In order to detect Zika virus, the researcher Zhao and his colleagues used fission yeast to study how fission yeast can help detect how pathogens affect cells. It was first used to make beer. After decades, fission yeast has been used by many scientists. Used to study the behavioral mechanisms of cells.
Researcher Zhao is a pioneer scientist using the fission yeast model to study HIV and barley yellow dwarf virus, so he is very familiar with fission yeast; in this study, the researchers studied 14 proteins and small peptides of Zika virus. Separation, followed by exposure of yeast cells to each protein to observe changes in cells, the researchers found that seven of them can damage yeast cells in a special way, inhibit cell growth and kill yeast.
Of course, the researchers' research does not stop there. They also hope to continue to work on Zika virus in the later period. They hope to understand the mechanism of action of the newly discovered seven proteins in the human body through research. Studies have elucidated the interaction between Zika virus and rat and human cells. Later, they hope to clarify the more molecular mechanisms of Zika virus infection in the body through joint research.
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