In recent years, CRISPR-Cas9 gene editing technology has achieved remarkable results. First, Editas announced the implementation of CRISPR gene editing human experiment in 2017. The excitement has not yet passed, and gene editing has been published from Great Ormond Street Children's Hospital. "Cure" explosive news of leukemia; followed by Wang Lihong began to introduce CRISPR gene editing technology on Weibo. The entrepreneurial youths who are struggling in the genetic circle are crying, "We finally found the spokesperson." Gene editing technology is really like this! And a domestic hospital team is at the forefront of the world with a solid scientific research spirit and excellent medical technology.
On November 15th, Nature published an article called "CRISPR gene-editing tested in a person for the first time", and just a few months ago, the journal published "Chinese scientists to pioneer first". Human CRISPR trial" article, two articles of research team from a place, that is China West China Hospital.
On July 22nd, Lu Yu team of oncologists from West China Hospital of Sichuan University in Chengdu, they plan to start testing in humans for lung cancer cells in August. Now, to what extent has the experiment progressed? According to a report in the journal Nature today, it was confirmed that the team of Professor Lu Yu of Huaxi Hospital has opened the world's first human body application of CRISPR technology.
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On July 6th, Professor Lu Yu’s application for the CRISPR human clinical trial has been approved by the Huaxi Hospital Review Committee. The clinical trial is for non-small cell lung cancer, and the cancer has spread, chemotherapy and radiotherapy. And patients with other treatments that have been ineffective. According to the plan, Professor Lu Uun's team isolated T cells from recruited patients, and used CRISPR technology to genetically edit these cells, knock out the PD-1 gene that inhibits immune function in these cells, and perform cell expansion in vitro. . When the cells reached a certain amount, Professor Lu’s team returned them to the patient and hoped they could kill the tumor. Lu Yu said: "The treatment plan is very limited. This technology has great hope for some patients, especially the cancer patients we treat every day."
At present, the researchers have completed the final step of the previous experiment, injecting the genetically edited cells into the patient, and intend to perform the same experiment on the other 9 patients. It will take 6 months for the results to be revealed to see if the treatment can benefit these “drug-free†patients and whether they have serious side effects. Next, the research team plans to treat a total of 10 patients, each of whom will receive 2-4 injections.
Some foreign oncologists worry that the application of CRISPR gene editing technology in human body is still controversial, and it may also edit the genome in the wrong place, causing physical damage to the patient and sometimes triggering new cancer. Chinese scientists say they will validate the cells and confirm that the correct genes are knocked out before returning the cells to the patient.
However, many oncologists at home and abroad are still very excited. They think that the editing of CRISPR-Cas9 gene into human trial stage is a great leap in history, bringing hope to lung cancer patients in China and the world. Foreign media believe that China has become the first country in the world to have this technology. This major breakthrough will trigger a new round of competition between China and the United States in the field of biomedicine.
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Humans use genetic editing for the first time to treat leukemia
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