Release date: 2014-07-14
Recently, researchers from NIH found that a similar situation in humans, that is, mice drinking low-dose arsenic drinking water may cause lung cancer, the related research published in the international magazine Archives of Toxicology.
The arsenic content in public drinking water should not exceed 10 parts per billion, which is the standard established by the US Environmental Protection Agency. However, millions of people are drinking private water wells that have no metrics.
In this study, mice were divided into three treatment groups, namely, the arsenic content of drinking water in mice was 50 parts per billion, 500 parts per billion and 5,000 parts per billion. In animal experiments, 50 points is the lowest dose group. Due to the different metabolic rate, mice need to use higher doses of arsenic-containing water to achieve the desired effect compared to humans.
Researchers use animal models to mimic how humans make contact with arsenic throughout their lives. In this study, arsenic was administered to mice for the entire production, pre-pregnancy and lactation for three weeks, and the offspring of the mice were given arsenic after weaning. The concentration of arsenic in the adult adulthood was related to human exposure. . The researchers finally found tumors in adult adult offspring.
“This is the first study to show that tumors are produced in animals exposed to very low levels of arsenic. This exposure dose is similar to human exposure,†Dr. Michael Waalkes said. “This result is unexpected, and this is also of concern. the reason".
Arsenic is a natural substance found in the environment or a substance produced by the pollution of human activities. Because it can be absorbed from soil and water, it causes the presence of arsenic in many foods including cereals, fruits and vegetables. . The excessive concentration of inorganic arsenic in this study exists in the drinking water of millions of people around the world and has been proven to be a human carcinogen.
In this study, more than half of the male mice in the two low-dose (50:500) treatment groups had significantly increased benign and malignant lung tumors, and the benign tumors produced by female offspring increased. Interestingly, the researchers did not find an increase in the number of lung cancer mice in the highest dose group (5000 points) of the amphipathic mice.
“Although this is only a study, there is growing evidence that long-term exposure to low arsenic can have a very negative health impact, and the environment without arsenic exposure is relatively safe,†said Dr. Linda Birnbaum.
Source: Bio Valley
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