[China Pharmaceutical Network Technology News] Recently, an experimental cancer treatment drug research conducted by the University of Virginia School of Medicine showed that the drug can effectively treat melanoma. In addition, the drug also works for melanoma that has already been resistant to other drugs. If the drug is further developed, it will bring good news to patients who have failed initial treatment.
The drug, called pevonedistat, has begun to enter clinical trials. But because this drug can shut down the expression of many different proteins, scientists have been unaware of the exact mechanism by which the drug kills cancer cells.
In this study, the researchers demonstrated that the drug can act on a particular protein, and melanoma cells and other cancer cells rely on this protein for rapid replication.
This important protein that blocks the blockade of melanoma pevonedistat is the expression product of the CDT2 gene, which is very important for the survival of malignant cancer cells. The lack of this protein will stop replication and begin to apoptosis.
"We have a deep understanding of the mechanism by which this drug works," the researchers said. "We don't think this drug works on the original target, but on the downstream of the original target (CDT2)."
Studies have found that CDT2 is overexpressed in melanoma cells, and patients with high expression of this protein are less likely to survive.
"Not only melanoma, but other tumors also depend on this gene, which makes these tumors very susceptible to this drug. In fact, we found that the higher the expression of CDT2 in melanoma cells, the more susceptible it is to the drug. â€
The safety and efficacy of this drug is still in the experimental stage and therefore cannot be used as a clinical treatment.
But researchers are optimistic about clinical trials based on their research. "We think this drug will have a significant impact on melanoma patients. In fact, this drug is very effective for all melanomas, even those that still have no effective treatments. If the FDA approves the drug for further development For those patients who initially failed treatment, the drug is expected to be a good second-line treatment."
(Scientists will solve the melanoma mechanism of action and will develop new drugs in depth)
The drug, called pevonedistat, has begun to enter clinical trials. But because this drug can shut down the expression of many different proteins, scientists have been unaware of the exact mechanism by which the drug kills cancer cells.
In this study, the researchers demonstrated that the drug can act on a particular protein, and melanoma cells and other cancer cells rely on this protein for rapid replication.
This important protein that blocks the blockade of melanoma pevonedistat is the expression product of the CDT2 gene, which is very important for the survival of malignant cancer cells. The lack of this protein will stop replication and begin to apoptosis.
"We have a deep understanding of the mechanism by which this drug works," the researchers said. "We don't think this drug works on the original target, but on the downstream of the original target (CDT2)."
Studies have found that CDT2 is overexpressed in melanoma cells, and patients with high expression of this protein are less likely to survive.
"Not only melanoma, but other tumors also depend on this gene, which makes these tumors very susceptible to this drug. In fact, we found that the higher the expression of CDT2 in melanoma cells, the more susceptible it is to the drug. â€
The safety and efficacy of this drug is still in the experimental stage and therefore cannot be used as a clinical treatment.
But researchers are optimistic about clinical trials based on their research. "We think this drug will have a significant impact on melanoma patients. In fact, this drug is very effective for all melanomas, even those that still have no effective treatments. If the FDA approves the drug for further development For those patients who initially failed treatment, the drug is expected to be a good second-line treatment."
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