Last night, Xiaobian’s circle of friends was screened by a message, “23andMe gave up NGS detection technology and hoped to focus on the core businessâ€. In the eyes of founder Wojcicki, NGS is really hot, but the sequencing information is very complicated.
23andMe offers products that are directly consumer-oriented and have very clear results. Since there are more expensive disease-specific tests available on the market, they don't go to "eggs and stones."
At the recent WSJD Live conference hosted by The Wall Street Journal, 23 and Me founder Anne Wojcicki acknowledged that the company has stopped working on NGS testing and dismissed a team of scientists and an executive. She pointed out that NGS is more complicated and expensive than the current test, and the NGS test market is still in the “infancyâ€, and the company is more willing to focus on its “core businessâ€.
.jpg)
What is the “core business†of 23andMe?
That is, based on SNP (DNA sequence polymorphism caused by variation of single nucleotide at the genomic level), 650,000 sites in the human genome are detected to form large-scale, voluntary population genetic sampling and Gene component type work.
1. Take the road of mass consumption, genetic testing is enough
In Anne Wojcicki's view, next-generation sequencing (NGS) is really hot, but the sequencing information is very complicated. What do you do if the interpretation shows that your chances of developing breast cancer are 5%? This is a very complicated and unclear question.
And 23andMe offers products that are directly consumer-oriented, which means that the results he provides need to be very clear. Since there are already more expensive disease-specific tests available on the market, they don't go to "eggs and stones."
When it comes to 23andMe's detection technology, I have to mention it here.
Professor Paul Cannon, head of the 23andMe Parkinson's disease research community and star scientist, said in an interview that the company's products are based on SNP (DNA sequence polymorphism caused by single nucleotide variation at the genomic level), on the human genome. The detection of 650,000 sites is a milestone in sequencing technology (not NGS), and the single nucleotide diversity constitutes the diversity of different individuals.
What are the advantages of SNP? The author takes time mass spectrometry as an example. The method utilizes the principle that the flight time of the sample molecule in the electric field is proportional to the mass-to-charge ratio of the molecule, and the molecular weight is measured by detecting the flight time of the sample molecule, and the SNP site is inferred. It is reported that the accuracy of the gene detection is 99.7%, which is much higher than the accuracy of the gene chip, and the cost is lower than that of the second generation. SNP classification detection technology has the advantages of high accuracy, strong flexibility, large throughput, short detection period and low cost; the advantage of data analysis is fast, accurate and standardized.
2. The business model of "making money at both ends"
23andMe has several big gold owners, including Google, Facebook, etc., so the financial strength is relatively sufficient, but the work has always been to burn money, rather than relying solely on a technology-driven company.
Since its inception, 23andMe has set up two different lines of business: one is to sell its genetic services to individual consumers, and the other is to sell consumer genetic data to drug development or biotechnology companies.
In the beginning, 23andMe's "two-headed money" approach caused industry concerns, but from the recent review, 23andMe seems to have entered a virtuous circle.
On the one hand, 23andMe began to enter the public eye after being stopped by the FDA in 2013. The $99 DNA test kit has given it a lot of information, so it's natural to get a lot of genomic information on the road to selling information, which is exactly the same as Google's. Today, 23andMe has quietly owned 1.2 million complete data using a variety of methods, including genomes and user data that have been sequenced, which can be found on the phone anytime, anywhere.
On the other hand, 23andMe is a member of the personalized medical industry . In 2006-2007, a group of passionate startups emerged, they promised to extract customer DNA and generate personalized medical reports to help customers understand the health risks lurking in genes, but they also face huge survival pressures. Unfortunately, 23andMe became the only survivor of these startups.
Probiotics are a class of active microorganisms that are beneficial to the host by colonizing the human body and changing the composition of the flora in a certain part of the host. By regulating the immune function of the host mucosa and system or by regulating the balance of intestinal flora, promoting nutrient absorption and maintaining intestinal health, resulting in the production of single microorganisms or mixed microorganisms with a well-defined composition that are beneficial to health
Probiotics,Acidophilus Lactobacillus,Lactobacillus Acidophilus,Lactobacillus Salivarius
SHAANXI HAIBO BIOTECHNOLOGY CO., LTD , https://www.rozenbio.com