For a long time, in the production of solid preparations in the pharmaceutical industry, the problem of powder material transportation between production stages has become an important issue in improving production processes and improving product quality. In China's solid preparation enterprises, the production methods of manual ingredients and manual feeding are common, such as a typical production process from one-step granulation drying to total mixing in a certain manufacturer:
Hopper [manual transfer] - intermediate bucket [manual feeding] - granulator [receiving] - intermediate bucket [manual] - mixer [discharge] - bucket
In this process, the contact between the person and the drug is three times, and the material can be used in the next step through three intermediate containers, which not only increases the labor intensity of the worker, but also makes the process cumbersome, and more importantly, it increases. The possibility of cross-contamination of materials, at the same time, in the process of transport, may cause a large amount of dust, pollute the environment, affecting the health of the operator. Some materials are also flammable, explosive, toxic, harmful and other special properties, which is even more unsuitable for this method. This is also the case in the process of tableting and capsule filling, and most domestic manufacturers still use manual feeding.
The ideal conveying method of Zui should be: to minimize the direct contact between people and materials, so that the material transportation can be completed in a closed environment, which can save labor, reduce costs, avoid cross-contamination, and improve solid preparations. The degree of automation of the production process has led to the emergence of vacuum feeders.
The vacuum feeder is a new product developed on the basis of extensive absorption of similar foreign products. At present, it is a vacuum conveying equipment for domestic, ideal and perfect powder materials, granular materials and powder materials. The vacuum feeder consists of a vacuum pump (oil-free, water-free), stainless steel suction nozzle, delivery hose, bag filter (or 316L stainless steel filter), rapping cleaner (or compressed air backflushing device), vacuum hopper and The material level automatic control device is composed of the same, and the whole system is designed reasonably and beautifully.
The vacuum feeder has a wide range of applications in the pharmaceutical industry. In the solid preparation workshop, it can be combined with a pulverizer, a vibrating screen, a wet granulator, a mixer, a coating machine, a tableting machine, a capsule filling machine, an aluminum-plastic packaging machine, The granule packing machine and the like are connected, and the vacuum is used to realize automatic feeding. In the Chinese medicine pill workshop, it can be connected with the screening machine, the boring machine, the pelleting machine, the shaping machine, the dryer, the coating machine, the blasting machine, the bottling machine, etc., and the vacuum is used to realize the automatic feeding. In addition, the vacuum feeder is used in the traditional Chinese medicine pre-treatment workshop, the Chinese medicine extraction workshop and the raw material medicine dry packaging workshop.
(1) Dust-free feeding of the pulverizer
The vacuum feeding machine is placed on the inlet of the pulverizer, and is tightly connected with the hopper. A material level sensor is arranged on the hopper, and the material feeding device is controlled to control the vacuum feeding machine to realize automatic feeding.
(2) Dust-free feeding of the mixer
The two-dimensional or three-dimensional mixer can be continuously loaded, and needs to be matched with a customized interface to place the in-situ cleaning device of the titanium metal filter in the mixing machine cavity, and the integrated closed connection avoids cross-contamination and dust flying, reducing Material and energy loss.
(3) Vacuum feeding of the tablet press
The vacuum feeding of the tablet press needs to solve three major problems: one is to prevent stratification of the powder particles, the other is to ensure that the material level difference in the hopper is constant, and the third is to eliminate the static electricity of the material. At present, these problems are completely solved by scientific airflow model and soft landing technology, material level detection technology and static elimination technology. Ensure that the difference in tablet weight and molding are up to standard.
(4) Feeding of the reactor
The vacuum feeder was tightly mounted on the feed port of the reaction vessel, and the material was sucked into the reaction vessel. Sometimes in order to achieve a uniform feed, it is necessary to increase the continuous feeding device.
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