99% High Purity Sorafenib Tosylate for Anticancer Drug CAS 475207-59-1

Product Description

 

Product Name:Sorafenib tosylate
Other Name:Sorafinib mesylate;1-(4-Chloro-3-(trifluoroMethyl)phenyl)-3-(4-((2- (MethylcarbaMoyl)pyridin-4-yl)oxy)phenyl)urea Mono(4- Methylbenzenesulfonate);4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate
CAS:475207-59-1
MF:C21H16ClF3N4O3.C7H8SO3
MW:637.03
Assay:99%min
Appearence:White crystalline powder
Drug category:Anticancer drug
Purpose:This product is mainly used for the treatment of liver and renal cell carcinoma of the clinical anti-cancer agents.
Package:1kg/bag

Function&Usage

Sorafenib tosylate, also named nexavar, is a small-molecule anticancer compound. It is also a novel oral Raf kinase and a vascular endothelial receptor (VEGFR) inhibitor. It inhibits tumor cell proliferation and tumor angiogenesis [2]. To HepG2 cells (1× 106), the IC50 of sorafenib tosylate is 2.09μg/ml.  
Raf is a mitogen-stimulated protein kinase that functions as a component of the signaling cascade that leads to the stimulation of mitogen-activated protein kinase.
Vascular endothelial (VEGF) is a highly specific mitogen for vascular endothelial cells.
Treatment with nexavar potently inhibited the cell proliferation of MV4-11 cells (FLT3-ITD) in a dose-dependent manner with an IC50 of 0.88 nM. In MV4-11 cells, sorafenib tosylate of a concentration of 100 nM induced 43.6±5.2% of the cells to undergo apoptosis whereas in EOL-1 cells a concentration as low as 10 nM induced 89.29±1.8% of the cells to be apoptotic.
Nude rats at the age of 6 weeks injected with 105 MDA-MB-231 cells were involved. After monotherapy with sorafenib tosylate a significant reduction of the osteolytic lesion volume was observed on days 45 and 55 and of the soft tissue component volume on day 55 in comparison to untreated animals (p < 0.05). Compared to controls, treatment with sorafenib tosylate made bone metastases show significantly decreased values of Amplitude A and kep from day 35 to 55 (Amplitude A: p<0.01; kep p<0.01 on days 35 and 55; p<0.05 on day 45)

COA:

 Our Factory and Service:




How to make an order :

1. Name what your need ( which product , quantity )
2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .

Payment and Shipping:



Packaging:

Our service:

1.We have experience in exporting Pharmaceutical intermediates .
2.Professional packing with professional materials
3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
If any new enquiry,please feel free to contact us!

Our Advantages:

1,High quality under strict QC/QA system with GMP factory price
2,Fast and safe delivery with secure and discreet shipment
3,Providing complete services with our resource integration, we can thus create more competitive
advantages for you!

Product Description

 

Product Name:Sorafenib tosylate
Other Name:Sorafinib mesylate;1-(4-Chloro-3-(trifluoroMethyl)phenyl)-3-(4-((2- (MethylcarbaMoyl)pyridin-4-yl)oxy)phenyl)urea Mono(4- Methylbenzenesulfonate);4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate
CAS:475207-59-1
MF:C21H16ClF3N4O3.C7H8SO3
MW:637.03
Assay:99%min
Appearence:White crystalline powder
Drug category:Anticancer drug
Purpose:This product is mainly used for the treatment of liver and renal cell carcinoma of the clinical anti-cancer agents.
Package:1kg/bag

Function&Usage

Sorafenib tosylate, also named nexavar, is a small-molecule anticancer compound. It is also a novel oral Raf kinase and a vascular endothelial receptor (VEGFR) inhibitor. It inhibits tumor cell proliferation and tumor angiogenesis [2]. To HepG2 cells (1× 106), the IC50 of sorafenib tosylate is 2.09μg/ml.  
Raf is a mitogen-stimulated protein kinase that functions as a component of the signaling cascade that leads to the stimulation of mitogen-activated protein kinase.
Vascular endothelial (VEGF) is a highly specific mitogen for vascular endothelial cells.
Treatment with nexavar potently inhibited the cell proliferation of MV4-11 cells (FLT3-ITD) in a dose-dependent manner with an IC50 of 0.88 nM. In MV4-11 cells, sorafenib tosylate of a concentration of 100 nM induced 43.6±5.2% of the cells to undergo apoptosis whereas in EOL-1 cells a concentration as low as 10 nM induced 89.29±1.8% of the cells to be apoptotic.
Nude rats at the age of 6 weeks injected with 105 MDA-MB-231 cells were involved. After monotherapy with sorafenib tosylate a significant reduction of the osteolytic lesion volume was observed on days 45 and 55 and of the soft tissue component volume on day 55 in comparison to untreated animals (p < 0.05). Compared to controls, treatment with sorafenib tosylate made bone metastases show significantly decreased values of Amplitude A and kep from day 35 to 55 (Amplitude A: p<0.01; kep p<0.01 on days 35 and 55; p<0.05 on day 45)

COA:

 Our Factory and Service:




How to make an order :

1. Name what your need ( which product , quantity )
2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .

Payment and Shipping:



Packaging:

Our service:

1.We have experience in exporting Pharmaceutical intermediates .
2.Professional packing with professional materials
3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
If any new enquiry,please feel free to contact us!

Our Advantages:

1,High quality under strict QC/QA system with GMP factory price
2,Fast and safe delivery with secure and discreet shipment
3,Providing complete services with our resource integration, we can thus create more competitive
advantages for you!

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