Shao Yifu Hospital doctor found three kinds of drugs against Zika virus
September 13, 2016 Source: Ningbo Net
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];On September 2, Cai Xiujun, dean of the Sir Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine, received a good news from the United States. The hospital sent to the National Center for Translational Sciences (NCATS) to study the intensive medical doctor Xu Miao, August. On the 29th, as the first author, in the American authoritative magazine "Nature Medicine" ("NatureMedicine") published the topic of "Zika virus effective treatment drugs" research.
Since there is no vaccine against Zika virus and no corresponding treatment drugs, the Zika virus epidemic has spread around the world in the past. Recently, more and more confirmed cases in Singapore and Malaysia have attracted people's attention. The medical profession also faces greater challenges in the prevention and treatment of Zika virus.
At present, scientists are studying the Zika vaccine and developing new drugs intensively to cope with the increasingly severe Zika epidemic. However, Xu Miao and American researchers have taken a different approach to find three classes of effective drugs in more than 6,000 known drugs.
Therefore, once the issue was published, it caused a sensation. On the same day, the Wall Street Journal, The Washington Post, the National Institutes of Health (NIH), and many mainstream media in Europe and the United States reported on this.
The process of recalling the research, Xu Miao, who is still doing research in the United States, has experienced many problems and challenges. In March of this year, Xu Miao’s National Center for Translational Medicine, in collaboration with Johns Hopkins University and Florida State University, decided to jointly study drugs for the treatment of Zika virus infection.
As the most important bearer of this research, Xu Miao's life has been occupied by experiments since then, and it has become the norm around the clock, with almost no rest days. Xu Miao told reporters that because the study used live Zika virus, it is dangerous, so the laboratory has limited the people who can do this research. Therefore, Xu Miao in the laboratory, alone to complete the screening of more than 6,000 alternative drugs, and then cooperate with the cooperation unit to further confirm the efficacy of the drug and possible mechanisms of action.
As a Chinese clinician, Xu Miao has participated in the fight against SARS and avian flu viruses and has rich practical experience, which laid the foundation for her research. "How to do research with living viruses, how to do self-protection, how to ensure the safety of laboratories and other personnel, my partners and I have done a very comprehensive preparation." Xu Miao said.
After more than three months, Xu Miao and other researchers have finally found three effective drugs in more than 6,000 alternative drugs: Empricasan can effectively protect brain nerve cells from Zika virus, Niclosamide and CDK inhibitors. It can effectively inhibit the replication of viruses, and has synergistic antiviral effects with each other. At the same time, they are effective against the Zika virus of the African, Asian and Puerto Rican types.
On August 29, Xu Miao and the results of the American researchers "Study on anti-Zika virus infection and treatment of small molecule drugs caused by neuronal necrosis" were published in the authoritative journal Nature Medicine. It is worth noting that the researchers not only found effective drugs for the treatment of Zika virus, but also deposited all drug screening results into an open PubChem database, shared with researchers around the world, and made research for Zika virus. A positive contribution.
"This study is mainly about the discovery of new uses by old drugs." Xu Miao introduced that this article is a new beginning. After these drugs have undergone animal and clinical trials, they may eventually be used for Zika virus treatment, so they are still keep it up. Xu Miao is also optimistic that Niclosamide is an insecticide that has been approved by the US Food and Drug Administration (FDA) and is non-toxic during animal testing, so it may be the first to be used for Zika virus. Clinical treatment.
“Run Shaw Hospital has always attached great importance to cooperation and exchanges with top medical and research institutions abroad, and insisted on the open-ended talent training and academic exchange mode of coming in and going out.†Cai Xiujun believes that Xu Miao’s scientific research achievements have sprung up internationally. It is the result of the hospital's insistence that young and middle-aged doctors must fully develop their clinical and scientific research capabilities.
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