Why breast cancer is not common in common heart cancer
August 15, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Malignant cancers tend to favor certain organs, such as the colon and breast; in a recent study published in the international journal Trends in Cancer , researchers from the French Center for Ecology and Evolutionary Cancer found that certain organ pairs The susceptibility of cancer may depend on natural selection. Larger or paired organs in the body tend to be more tolerant to tumors than some small, vital organs, such as the heart, so large organs tend to evolve. There are fewer mechanisms to counteract the invasion of cancer cells.
Evolutionary biologist Frédéric Thomas says that organs that can sustain our survival and continue to reproduce, such as the heart, brain or uterus, generally have better resistance to cancer (all other factors being equal), but that doesn't mean, It is a major factor that can explain the different susceptibility of organs to cancer; many oncologists often explain organogenesis by analyzing external risk factors such as smoking or ultraviolet radiation, and internal factors such as cell division in tissues. The difference.
Now researchers have proposed a certain evolutionary theory to complement the current interpretation and understanding. Researchers point out that natural selection is more likely to provide anti-cancer protection for small organs that are critical to human survival and reproduction. Large or paired organs tend to accumulate large amounts of carcinogenic properties without damage. Similar to small, important organs such as the pancreas, it is easy to compromise the tumor. In theory, if all factors are the same, the pancreas should be better able to fight cancer than organs such as kidneys, and the anti-cancer protection is different in different organs, but generally These protective effects will make the organ tolerant to the formation of tumors.
Researcher Thomas pointed out that cancer biologists now believe that a single organ can be used as a special "island" with its own environmental conditions, including oxygen, acidity levels and water content, so cancer cells survive in a single organ. Depending on the environment in which they live, malignant cancer cells are some living solid structures that are almost impossible to be affected by ecological conditions, which obviously means that specific organs in the body tend to be more beneficial to malignancy than other organs. Cell survival and reproduction.
Now researchers are experimenting with this hypothesis, and researchers need to take all possible confounding factors into account before they can perform a complete analysis. Thomas emphasizes that we can't see the statistical data of cancer and the size of organs. But we can link the two to see if they have a certain correlation. Our research team is currently conducting a long-term study of mice to determine the accumulation of cancer and precancerous mutations in different organs of the mouse; the assumptions about evolutionary selection are well worth exploring, and we hope that this study will allow more scientists. We are doing research and efforts in this direction.
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