Recently, the regenerative medicine company TissueGene, based in Maryland, announced that its partner in Asia (including South Korea), Kolon Life Science, has obtained a listing license from Invossa from the Korea Food and Drug Safety (MFDS). The world's first marketed cell and gene therapy for degenerative arthritis.
Osteoarthritis is the most common type of arthritis. The main cause of this is that the cartilage layer in the joint is damaged and worn out, causing the bones under the cartilage to rub against each other. This results in joint pain, swelling, and reduced range of motion in the patient. As the disease progresses, the joint may deform or grow spurs. Skeleton and cartilage fragments floating in the joint cavity may cause more pain and damage. Current common methods of treating osteoarthritis include oral anti-inflammatory analgesics, injection of steroids or hyaluronic acid into the joints, and joint replacement surgery. Most of these therapies only temporarily relieve the pain, and joint replacement is expensive and accompanied by the risks of surgery.
Normal joint (left) and osteoarthritis (right) (Source: healthnavigator.org)
The Invossa developed by TissueGene is a first-in-class cell gene therapy. It uses a retroviral vector to express TGF-β1 protein in allogeneic chondrocytes. These highly expressed TGF-β1 chondrocytes undergo a series of screenings to minimize the patient's immune rejection of the cells. These genetically engineered chondrocytes can then be injected into the joints of the patient with unmodified chondrocytes, which will become the "protein manufacturing plant" within the joint, expressing and releasing TGF-β1 to promote cartilage. Tissue repair and regeneration.
The world's first degenerative arthritis gene therapy drug Invossa (Source: Korea Central Daily)
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