The polymerase [poly(ADP-ribose) polymerase, PARP] can transfer ADP ribose monomer to the substrate protein with NAD+ as substrate, and catalyze the synthesis of poly ADP-ribose [PAR, poly (ADP-ribose) Polymer PAR polymer. During the PARP self-modification process, the charge of PARP will increase, resulting in dissociation from DNA and loss of activity. Studies have found that inhibition of PARP can prevent tissue damage in diseases such as myocardial and neuro-ischemia, diabetes, septicemia, stroke, etc., and even contribute to chemotherapy and radiosensitization in cancer treatment. Research on PARP inhibitors has received extensive attention from researchers at home and abroad!
As a new target for cancer therapy today, poly(ADP-ribose) polymerase (PARP) catalyzes the ADP-ribose unit from nicotinamide Adenine Dinucleotide (Nicotinamide Adenine Dinucleotide, NAD+) is transferred to various receptor proteins. PARP is involved in DNA repair and transcriptional regulation, which plays a key role in regulating cell survival and death, and is also a major transcription factor in tumor development and inflammation.
PARP plays a key role in the repair of DNA single-strand breaks (SSBs) repaired by base excision, and inhibition of its activity enhances the efficacy of radiotherapy and DNA-damaging chemotherapy drugs. At least 8 PARP inhibitors have been introduced into the clinic. The latest in vitro and in vivo experiments show that PARP inhibitors can not only act as chemotherapeutic sensitizers, but also selectively kill tumor cells with defective DNA repair, such as BRCA1 and BRCA2 defects. Breast cancer cells. Amy Jie recommends a variety of PARP inhibitor products and select some of the best-selling products for you as follows:
3-Aminobenzamide is a competitive PARP inhibitor with a Ki of 1.8 μM. In vitro studies have shown that 3-Aminobenzamide produces a rapidly reversible change in the frequency of single-strand breaks in the DNA of primary human fibroblasts damaged by alkylating agents. ABT-888 (veliparib) is a potent PARP-1 and PARP-2 inhibitor with an IC50 of 5.2 and 2.9 nmol/L and also inhibits SIRT2.
Amy Jie provides you with a one-stop PARP-related experimental solution, in addition to PARP inhibitors, PARP-related antibodies, assay kits, such as high-throughput PARP/apoptosis assay kits, and pharmacodynamics of PARP in vivo The second generation assay kit (PDAII) and the universal PAPR assay kit (containing histone coated detachable plates).
Trevigen is a fast-growing US biotechnology company focused on oncology research products and services for apoptosis, DNA damage and repair, tumor cell function and behavior. As Trevigen's general agent in China, Amy Jie and Trevigen provide Chinese researchers with the best and most up-to-date quality products and technical services in areas such as oxidative stress, cell damage and tumor cell behavior research. If you are interested in the above products and solutions, please contact Ai Meijie Technology Co., Ltd. for an experimental solution for angiogenesis research, or request the latest product information.
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